Multidisciplinary Cancer Investigation
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Volume 1 - Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress
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Matluobi Z, Saraf Hasan Z, Amir Kalvanagh P. Novel Curcumin Nano Formulations for Breast
Cancer. Multidiscip Cancer Investig 2017; 1
URL: http://mcijournal.com/article-1-104-en.html
URL: http://mcijournal.com/article-1-104-en.html
Abstract: (4741 Views)
Introduction: Curcumin is a natural yellow compound that is obtained from Curcuma
longa. Curcumin is found in two forms of ketone and enol that in PH > 8, enol form is
predominant. In enol form, curcumin acts as a potent antioxidant by losing its proton and
reduction of free radicals. However, curcumin has had very low dissolution in water and
its ketone form has been predominant in acidic conditions (the PH of environment surrounding
the tumor is acidic). In addition, degradation rate of curcumin by enzyme and
its elimination from the bloodstream is very high. So, the antioxidants effects of curcumin
in the body have had greatly reduce. Today, scientists have promising that nanoparticles of
curcumin can to overcome at these problems. In this study, has used of a new curcuminalbumin
Nano formulation and measured its effect on MCF 7 and PBMC cells.
Materials and Methods: After making of curcumin- albumin Nano drug, anticancer effects
of its have been examined by MTT and flow cytometry tests on MCF7 and PBMC
cells.
Results: The MTT test showed that in the first 24 hours, the antioxidant effect of free
curcumin and Nano drug has been similar and after 48 hours, curcumin antioxidant properties
has reduced but Nano drug antioxidant properties have not changed. For normal
cells, the results were almost the same. Flow cytometry has shown that at 54 μmol concentration,
free curcumin and Nano drug have led to 74% and 83% apoptosis in MCF 7 and
survival value of PBMC was 84% and 92%, respectively.
Conclusions: Nano-curcumin drug increase curcumin solubility in water and its stability
in physiological and acidic conditions. These, have been able it to overcome the limitation
of use of curcumin.
longa. Curcumin is found in two forms of ketone and enol that in PH > 8, enol form is
predominant. In enol form, curcumin acts as a potent antioxidant by losing its proton and
reduction of free radicals. However, curcumin has had very low dissolution in water and
its ketone form has been predominant in acidic conditions (the PH of environment surrounding
the tumor is acidic). In addition, degradation rate of curcumin by enzyme and
its elimination from the bloodstream is very high. So, the antioxidants effects of curcumin
in the body have had greatly reduce. Today, scientists have promising that nanoparticles of
curcumin can to overcome at these problems. In this study, has used of a new curcuminalbumin
Nano formulation and measured its effect on MCF 7 and PBMC cells.
Materials and Methods: After making of curcumin- albumin Nano drug, anticancer effects
of its have been examined by MTT and flow cytometry tests on MCF7 and PBMC
cells.
Results: The MTT test showed that in the first 24 hours, the antioxidant effect of free
curcumin and Nano drug has been similar and after 48 hours, curcumin antioxidant properties
has reduced but Nano drug antioxidant properties have not changed. For normal
cells, the results were almost the same. Flow cytometry has shown that at 54 μmol concentration,
free curcumin and Nano drug have led to 74% and 83% apoptosis in MCF 7 and
survival value of PBMC was 84% and 92%, respectively.
Conclusions: Nano-curcumin drug increase curcumin solubility in water and its stability
in physiological and acidic conditions. These, have been able it to overcome the limitation
of use of curcumin.
Select article type: Original/Research Article |
Subject:
Materials Science and Nanomedicine
Received: 2017/10/28 | Accepted: 2017/10/28 | ePublished: 2017/10/28
Received: 2017/10/28 | Accepted: 2017/10/28 | ePublished: 2017/10/28
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