Volume 0 - Multidisciplinary Cancer Investigation                   Multidiscip Cancer Investig 2025, 0 - Multidisciplinary Cancer Investigation: 31-46 | Back to browse issues page

XML Print

Oncometabolites: The Metabolic Shadow of Oncogenes
Zahra Sheikhi1 , Mohtaram Vafakhah2 , Hamed Mirzaei2 , Mahdieh Khosravi2 , Kambiz Gilany *3
1- Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
2- Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
3- Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran & Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran , k.gilany@avicenna.ac.ir
Abstract:   (446 Views)
Oncometabolites such as L-lactate, succinate, fumarate, R-2-hydroxyglutarate, kynurenine, and itaconate are emerging as pivotal drivers of cancer progression. Beyond their metabolic roles, these molecules function as signaling mediators that remodel epigenetic landscapes, reprogram the tumor microenvironment, and promote immune evasion. This review synthesizes current insights into their biochemical origins, oncogenic mechanisms, and therapeutic potential, highlighting how targeting oncometabolite-driven pathways could facilitate the development of novel cancer therapies.
Keywords: Fumarate , Iltaconate , Kynurenine , L-lactate , Oncometabolites , R-2-Hydroxyglutarate , Succinate
Full-Text [PDF 417 kb]   (330 Downloads)    
Select article type: Review Article | Subject: Molecular Mechanisms
Received: 2024/09/4 | Accepted: 2024/12/13 | ePublished: 2025/09/22
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.