Volume 1 - Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress                   Multidiscip Cancer Investig 2017, 1 - Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress: 0-0 | Back to browse issues page


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ShahidSales S, Baderi M, Anvari K, Avan A. The Prognostic Value of HER1 R497K in Patients with Breast Cancer. Multidiscip Cancer Investig. 2017; 1
URL: http://mcijournal.com/article-1-81-en.html
Abstract:   (1381 Views)
Introduction: Breast cancer is among the leading cause of cancer death in women. Despite extensive efforts to identify novel prognostic and predictive clinical biomarkers, a very small number of markers have been reported as risk stratification biomarker (e.g., BRCA1/2 and HER2). The substitution of arginine with lysine in codon 497 of HER1 497 has been suggested as a potential marker in breast cancer. The aim of current study was to explore the association between HER1 497 gene polymorphisms with pathological and clinical information of breast cancer patients.
Materials and Methods: 110 breast cancer patients were recruited followed by genomic DNA extraction and genotyping using RFLP_PCR and sequencing.
Results: Our data showed that 9.43% of cases had AA genotype, while these frequencies in AC and CC genotypes were 77.35 and 13.20%. Moreover, we found that 78.4% of breast cancer patients with M0 had AA+AC genotypes, while 21.6% of CC cases had M0 status. Also, 22.7% of these cases with CC genotype had N0/1. Interestingly we observed that most of the patients with CC genotype had lower HER2 expression.
Conclusions: Our finding showed the potential association of CC genotype of HER1 497 gene polymorphism with better prognosis of patients with breast cancer. Further studies are warranted to explore the prognostic value of this marker in a larger and multi center setting in breast cancer.
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Type of Study: Original/Research Article | Subject: genetics
Received: 2017/10/25 | Accepted: 2017/10/25 | ePublished: 2017/10/25

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