en Materials Science and Nanomedicine Original/Research Article Introduction: Curcumin is a natural yellow compound that is obtained from Curcuma<br> longa. Curcumin is found in two forms of ketone and enol that in PH > 8, enol form is<br> predominant. In enol form, curcumin acts as a potent antioxidant by losing its proton and<br> reduction of free radicals. However, curcumin has had very low dissolution in water and<br> its ketone form has been predominant in acidic conditions (the PH of environment surrounding<br> the tumor is acidic). In addition, degradation rate of curcumin by enzyme and<br> its elimination from the bloodstream is very high. So, the antioxidants effects of curcumin<br> in the body have had greatly reduce. Today, scientists have promising that nanoparticles of<br> curcumin can to overcome at these problems. In this study, has used of a new curcuminalbumin<br> Nano formulation and measured its effect on MCF 7 and PBMC cells.<br> Materials and Methods: After making of curcumin- albumin Nano drug, anticancer effects<br> of its have been examined by MTT and flow cytometry tests on MCF7 and PBMC<br> cells.<br> Results: The MTT test showed that in the first 24 hours, the antioxidant effect of free<br> curcumin and Nano drug has been similar and after 48 hours, curcumin antioxidant properties<br> has reduced but Nano drug antioxidant properties have not changed. For normal<br> cells, the results were almost the same. Flow cytometry has shown that at 54 &mu;mol concentration,<br> free curcumin and Nano drug have led to 74% and 83% apoptosis in MCF 7 and<br> survival value of PBMC was 84% and 92%, respectively.<br> Conclusions: Nano-curcumin drug increase curcumin solubility in water and its stability<br> in physiological and acidic conditions. These, have been able it to overcome the limitation<br> of use of curcumin. Curcumin, Albumin, Nano Drug, MCF7 0 0 http://mcijournal.com/browse.php?a_code=A-10-33-37&slc_lang=en&sid=1 Zahra Matluobi 10031947532846001055 10031947532846001055 Yes Zuhair Saraf Hasan 10031947532846001056 10031947532846001056 No Parisa Amir Kalvanagh 10031947532846001057 10031947532846001057 No