Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1396
7
1
gregorian
2017
10
1
1
Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress
online
1
fulltext
en
Anti-cancer Effects of Erlotinib (EGFR inhibitor) on Metastasis of Breast Cancer Cell Lines
Materials Science and Nanomedicine
Original/Research Article
<div style="text-align: justify;"><strong>Introduction:</strong> Breast cancer is the most common type of cancer found in women and today represents a considerable challenge to public health. Drug resistance is the main challenges for good prognosis of breast cancer patients. Recent clinical trials suggest that targeting of epidermal growth factor receptor (EGFR) could have a beneficent effect on many patients with cancer. Amplification/overexpression of the EGFR gene as a signature genetic abnormality of breast cancer tumors can be a chemo resistant mechanism.<br>
<strong>Materials and Methods:</strong> In this study, we use Erlotinib as an EGFR inhibitor. We evaluate the effects of this drug on metabolic activity, viability, colony formation potential and migration of BC cell lines, MDA-MB-231, SK-BR-3 and BT-474.<br>
<strong>Results: </strong>Our results showed that Erlotinib reduced metabolic activity, cell proliferation, and colony forming fraction in treated BC cell lines. We also found that wound-healing rate was decreased after treatment.<br>
<strong>Conclusions:</strong> Present study uncovered a mechanism whereby EGFR inhibition overcomes the resistance of BC cells. The Erlotinib significantly interfere with survival and migration of treated BC cell lines. Taken together, targeted therapies are going to enhance the efficacy of anti-cancer treatment.</div>
Anti-cancer, Erlotinib, Metastasis, EGFR
0
0
http://mcijournal.com/browse.php?a_code=A-10-33-56&slc_lang=en&sid=1
Ali
Zekri
10031947532846001067
10031947532846001067
No
Elham
Boustani pour
10031947532846001068
10031947532846001068
No
Zahra
Sadr
10031947532846001069
10031947532846001069
No
Seyed H.
Ghaffari
10031947532846001070
10031947532846001070
Yes