en Original/Research Article Introduction: Oxidative damage is one of the known mechanisms of progression and recurrence<br> of breast cancer during disease process, radiotherapy and chemotherapy courses,<br> taking anti-cancer drugs and the loss of aerobic fitness. Therefore, the purpose of this study<br> was to investigate the effect of six weeks of moderate-intensity aerobic exercise on lipid<br> peroxidation and antioxidant status of women survived of breast cancer.<br> Materials and Methods: In this semi experimental study, 19 women survived of breast<br> cancer with mean age (45.26 &plusmn; 2.87 years) and BMI (26.35 &plusmn; 2.37 kg/m2) were selected<br> based on inclusion criteria and then were randomly divided into two control (n = 10)<br> and experimental (n = 9) groups. Experimental group performed three sessions of aerobic<br> training at 60-70 HRmax each week and for 6 weeks. The first week trainings, ranging from<br> 60 to 65 HRmax, were conducted, until the end of the fifth week achieved to about 70<br> HRmax, and at sixth week continued with the same intensity. The control group did not<br> participate in any exercise program during this period. Blood sampling was conducted 24<br> hours before the first session and 48 hours after the end of the last training session. The<br> serum total antioxidant capacity (TAOC) and malondialdehyde (MDA) was measured by<br> ELISA kits. Data were analyzed by the use of dependent and independent t-test.<br> Results: A significant reduction in serum levels of MDA and a significant increase in<br> TAOC was observed in the experimental group (P = 0.003, P = 0.001).Aerobic fitness<br> improved significantly also (P = 0.001).<br> Conclusions: Regular moderate-intensity aerobic exercise can prevent the recurrence of<br> breast cancer by improving the body&rsquo;s antioxidant defense and aerobic fitness. Breast Cancer, MDA, TAOC, Moderate-Intensity Aerobic, Exercise 0 0 http://mcijournal.com/browse.php?a_code=A-10-33-81&slc_lang=en&sid=1 Samira Emadi 1003194753284600869 1003194753284600869 Yes Akbar Azamian Jazi 1003194753284600870 1003194753284600870 No Simin Hemmati 1003194753284600871 1003194753284600871 No