en Original/Research Article <div style="text-align: justify;"><strong>Introduction:</strong> Early detection and treatment of breast cancer may be helping to save of the lives of patients. Many new techniques have been urban to detect breast cancer. One of them is the use of nano-particles for accuracy and early diagnosis after photo transfer. In this study, we used gold nanoparticles which can change light source transfer intensity.<br> <strong>Material and Methods:</strong> Spherical gold nano particles and four types of bloods with 0,1, 2, 4 hemoglobin concentrations used for simulating of breast cancerous conditions. Nanoparticles with each concentrations of hemoglobin injected into the breast phantom including vessels and transmitted light intensity measured by power meter. Light source was near infra red At 635 wavelength.<br> <strong>Results:</strong> The intensity of the passing lights from hemoglobin concentrations of 0, 1, 2, and 4 were 9.31mw, 4.73mw, 3.36mw and 2.86mw, respectively in without nano particle condition. When the nano-particles were blended with hemoglobin concentrations of 0, 1, 2, and 4, the intensity of the passing light were 7.43mw, 3.62mw, 2.29mw and 2.02mw, respectively.<br> <strong>Conclusions:</strong> This study showed that addition of Spherical gold nano-particles to different concentration of hemoglobin provides a effective decline on the light transferring intensity.</div> Vascular Contrast, Hemoglobin, Nano-particles 0 0 http://mcijournal.com/browse.php?a_code=A-10-33-82&slc_lang=en&sid=1 Parinaz Mehnati 1003194753284600872 1003194753284600872 No Bahman Alipour 1003194753284600873 1003194753284600873 Yes Roya Salehi 1003194753284600874 1003194753284600874 No Behroz Shabani 1003194753284600875 1003194753284600875 No