en Original/Research Article <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Introduction</span></span></span></b><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">:</span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> This study aimed to investigate the effectiveness of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) for women with breast cancer.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Methods:</span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">It was a pilot randomized controlled trial in which women with breast cancer were allocated to a 9-week Unified Protocol for transdiagnostic treatment of emotional disorders (UP) (n=14) or a wait-list control group (n=15). Pre-and post-intervention, the Beck Depression Scale (BDI-II), Beck Anxiety Scale (BAI), Depression, Anxiety and Stress Scale (DASS-21), Cognitive Flexibility Inventory, Cognitive Emotion Regulation Strategies Scale (CERQ), Emotional Awareness Level Scale (LEAS), and The EORTC Breast Cancer-Specific Quality of Life (EORTC QLQ-BR23) were completed. </span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results:</span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Significant reductions in depressive, anxiety, and stress symptoms, as well as maladaptive emotional regulation strategies, were observed within the UP from baseline to post-treatment. Compared to the waitlist-control condition, participants in the UP condition showed increased adaptive strategies of emotional regulation, cognitive flexibility, mindful emotional awareness, and quality of life.</span></span></span></span></span></span><br> <b><span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">Conclusions:</span></span></span></b> <span style="font-size:12.0pt"><span style="line-height:107%"><span new="" roman="" style="font-family:" times="">The findings provide preliminary evidence for the utility of the UP in the reduction of psychological dysfunctions and improving the quality of life in women with breast cancer. </span></span></span> Protocol for Transdiagnostic Treatment of Emotional Disorders, Flexibility, Mindfulness, Emotional Regulation, Quality of Life, Breast Cancer 19 29 http://mcijournal.com/browse.php?a_code=A-10-392-2&slc_lang=en&sid=1 Fahimeh Rahimi rahimi.fahime@mail.um.ac.ir 10031947532846003879 0009-0008-3086-2660 No Department of Psychology, Faculty of Education Sciences and Psychology, Ferdowsi University of Mashhad, Mashhad, Iran Ali Mashhadi mashhadi@um.ac.ir 10031947532846003880 10031947532846003880 Yes Department of Psychology, Faculty of Education Sciences and Psychology, Ferdowsi University of Mashhad, Mashhad, Iran Zahra Hosseinzadeh Maleki z.hmaleki@ferdowsi.um.ac.ir 10031947532846003881 10031947532846003881 No Department of Psychology, Faculty of Education Sciences and Psychology, Ferdowsi University of Mashhad, Mashhad, Iran