en Review Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:&quot;Times New Roman&quot;,serif">3D nanoscale networks that are created with polymers physically or chemically are called Nanogels (NGs). Their biocompatibility, high stability, drug loading capacity, and ability to bind ligands for active targeting make them ideal for drug delivery systems. Moreover, they can respond to both internal and external stimuli, such as temperature, light, pH, and more. This makes it easier to consistently deliver the drug to the target area. Alginate (ALG) biopolymers are used for the encapsulation of anticancer drugs because of their biocompatibility, hydrophilicity, and affordability. These ALGs nanogel-based systems are effective in treating cancer, with several studies supporting their development. The ALG and its underlying systems are reviewed in this article.</span></span></span></span></span></span></div> Alginates, Gels, Drug Delivery, Cancer, Stimuli-Responsive 1 12 http://mcijournal.com/browse.php?a_code=A-10-57-8&slc_lang=en&sid=1 Hamid Reza Garshasbi hamidreza.garshsbi@yahoo.com 10031947532846003875 10031947532846003875 No Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, Iran Seyed Morteza Naghib naghib@iust.ac.ir 10031947532846003876 10031947532846003876 Yes Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology (IUST), Tehran, Iran