en Molecular Mechanisms Review Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:150%"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Lung cancer is a type of cancer that originates in the lungs, which are responsible for breathing. The p53 gene plays a critical crucial role in inhibiting cancer progression by regulating cell growth, DNA repair, and apoptosis. In lung cancer, p53 mutations are common and associated with aggressive tumor growth, chemotherapy resistance, and poor survival outcomes. This article reviews explores the etiological factors and therapeutic approaches related to p53 dysregulation in lung cancer.&nbsp; Early detection is key for improving treatment response success and patient survival. Research on p53 mutations in lung cancer has provided valuable insights into the molecular mechanisms driving tumorigenesis and treatment response. Targeted therapies for the treatment of lung cancer treatment have shown immense potential by targeting the p53 pathway. It is critical to understand the clinical significance of p53 mutations as they play a crucial role in determining the success of treatment and the patient&#39;s prognosis. Personalized treatment approaches must be considered, and future research should focus on developing new targeted therapies, expanding knowledge of p53 mutations in other cancer types, and improving diagnostic tools for to identifying p53 mutations in lung cancer patients. By investing in these areas, we can pave the way for more effective and personalized treatment for lung cancer patients.</span></span></span></span></span></span></div> <br> <br> <br> &nbsp; Lung, Cancer, p53, Mutation 1 15 http://mcijournal.com/browse.php?a_code=A-10-671-1&slc_lang=en&sid=1 Shahram Sadeghvand sadeghvandsh@tbmed.ac.ir 10031947532846004018 10031947532846004018 No Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Hadi Nasiri hadinasiri709@gmail.com 10031947532846004020 10031947532846004020 No Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Ali Sadighi ali.sadighi1996@gmail.com 10031947532846004019 10031947532846004019 No Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Javad Ahmadian Heris ahmadianj@tbzmed.ac.ir 10031947532846004021 10031947532846004021 No Department of Allergy and Clinical Immunology, Pediatric Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Parviz Shahabi parvizshahabi@gmail.com 10031947532846004022 10031947532846004022 No Department of Medical Physiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Navid Shomali shomali.navid@yahoo.com 10031947532846004023 10031947532846004023 No Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Reza Mohammadi Nasab rmn.nasab@gmail.com 10031947532846004024 10031947532846004024 No Department of History of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Sajjad Hejazi Sadjad.hijazi@neu.edu.tr 10031947532846004025 10031947532846004025 No Department of Anatomy, School of Veterinary Medicine, Near East University, Nicosia, North Cyprus Ali Bahadori Bahadoria@tbzmed.ac.ir 10031947532846004027 10031947532846004027 Yes Department of Medical Microbiology, Sarab University of Medical Sciences, Sarab, Iran Morteza Akbari Akbarimo@tbzmed.ac.ir 10031947532846004026 10031947532846004026 No Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran