en Biomedical Engineering and Technologies Review Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:12pt"><span style="line-height:150%"><span sans-serif=""><span style="font-size:14.0pt"><span style="line-height:150%"><span new="" roman="" times="">This review highlights the crucial role of polylactic acid (PLA)-based scaffolds in developing novel breast cancer treatment strategies. Despite advances in early detection and therapy, breast cancer remains a complex challenge with frequent resistance and relapse. Conventional treatments, while effective, have limitations such as restricted drug distribution and radiation toxicity. PLA scaffolds offer a promising alternative due to their biocompatibility and biodegradability, making them suitable for tissue engineering applications in oncology. The article examines the design and fabrication of PLA scaffolds that are not merely passive structures but play an active role in the therapeutic process. By tailoring their mechanical properties, these scaffolds can mimic the characteristics of actual breast tissue, creating a lifelike environment for studying cancer cell behavior. Furthermore, PLA scaffolds can mimic the tumor microenvironment, offering a three-dimensional representation that allows for a more accurate examination of tumor biology and treatment response. These scaffolds also function as advanced drug delivery systems, releasing therapeutic agents at the tumor site in a controlled manner, reducing systemic side effects, and enhancing drug efficacy. This review connects fundamental research with clinical practice, highlighting the revolutionary potential of PLA-based scaffolds in breast cancer management by mimicking the tumor microenvironment, delivering drugs locally, and enabling personalized treatment strategies.</span></span></span></span></span></span></span></div> Breast Cancer, Polylactic Acid, Scaffold, Tumor Microenvironment 0 0 http://mcijournal.com/browse.php?a_code=A-10-687-2&slc_lang=en&sid=1 Zanyar pirkani Zanyar.pirkani@ut.ac.ir 10031947532846003993 0009-0007-3378-8462 No Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Fatemeh Kamalinejad kamalinejad@ut.ac.ir 10031947532846003994 0009-0008-4314-9020 No Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Yasser Zare y.zare@aut.ac.ir 10031947532846003995 10031947532846003995 No Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran Seyyed Behnam Abdollahi Boraei be.abdollahi@ut.ac.ir 10031947532846003996 10031947532846003996 Yes Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran