Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1395
10
1
gregorian
2017
1
1
1
1
online
1
fulltext
en
Effect of Citalopram and Aspirin on Hot Flashes and Quality of Life in Premenopausal Women with Breast Cancer: A Randomized Double-blind Clinical Trial
Health Services, Quality of Life and Outcomes
Original/Research Article
<p style="text-align: justify;"><strong>Introduction: </strong>Over 70% of Iranian breast cancer patients are reported to have experienced an earlier menopause after chemotherapy. Due to the high and prevalent appearance of amenorrhea, this study focused on the efficacy of citalopram plus aspirin, compared to citalopram plus a placebo on cancerous women with chemotherapy-induced amenorrhea symptoms in premenopausal stages.<br>
<strong>Methods: </strong>In this randomized clinical trial study, 32 participants were randomly allocated to treatment (receiving citalopram and aspirin), and 28 to control (receiving citalopram and placebo) groups. Participants were selected from patients referring to Breast Cancer Research Center of ACECR, and Seyyed o-Shohada Hospital in Isfahan, Iran. To assess their functional, physical, emotional and socio-familial well-being, as well as their hot flashes, Functional Assessment of Cancer Therapy-General questionnaires were used, while the effect of treatment was measured using paired t-test and Wilcoxon signed-rank test.<br>
<strong>Results:</strong> The means of participants′ ages were 45.03 ± 5.1 and 44.7 ± 5.3 in treatment and control groups, respectively. Hot flashes decreased in both groups to a statistically significant degree, while no significant differences were observed in functional and sociofamilial well-being of participants before and after the treatment. The treatment group also displayed significantly improved emotional and physical well-being statuses after the treatment.<br>
<strong>Conclusions: </strong>The study demonstrated that premenopausal women undergoing chemotherapy for breast cancer experience disturbing symptoms such as hot flashes, and lower emotional and physical well-being, which can largely be treated with citalopram and aspirin. Relevant specialists and physicians could thus prescribe this drug regimen to alleviate these major symptoms.</p>
Premenopause Women, Drug Therapy, Hot Flashes, Breast Neoplasms.
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http://mcijournal.com/browse.php?a_code=A-10-77-2&slc_lang=en&sid=1
Safa
Najafi
10031947532846001180
10031947532846001180
No
Breast Diseases Department, Breast Cancer Research Center, ACECR , Tehran, Iran
Arezoo
Baktashian
10031947532846001181
10031947532846001181
No
Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Mandana
Ebrahimi
10031947532846001182
10031947532846001182
No
Cancer Quality of Life Department, Breast Cancer Research Center, ACECR , Tehran, Iran
Parisa
Mokhtari Hesari
10031947532846001183
10031947532846001183
Yes
Cancer Quality of Life Department, Breast Cancer Research Center, ACECR , Tehran, Iran
Mehdi
Rajabi
10031947532846001184
10031947532846001184
No
Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran