Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1396
7
1
gregorian
2017
10
1
1
Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress
online
1
fulltext
en
AKAP4 Gene Expression as a Candidate Breast Cancer Diagnostic Marker Detectable in Peripheral Blood
Materials Science and Nanomedicine
Original/Research Article
<div style="text-align: justify;"><strong>Introduction:</strong> Breast cancer is one of the most common types of cancer which causes death among women every year. More reports on breast cancer suggest that early diagnosis is important for improving clinical outcomes and overall survival in patients with breast cancer. Cancer testis antigens (CTAs) are considered as therapeutic targets, which are promising candidates in this field. In this context, we followed the expression of AKAP4 (cancer testis antigen that expressed in breast cancer tumors) in the peripheral blood as a possible diagnostic biomarker.<br>
<strong>Materials and Methods:</strong> To evaluate the expression of AKAP4 gene, nested real time RTPCR method with SYBR green dye was used in the blood and tissue of breast cancer patients compared with normal blood and breast tissue in the presence of an internal control in 120 samples.<br>
<strong>Results:</strong> Our data showed that the presence of AKAP4 gene expression in breast cancer tumor tissues and its subsequent detection in peripheral blood could be considered as a possible biomarker for breast cancer diagnosis even at the early stages.<br>
<strong>Conclusions: </strong>AKAP4 gene expression analysis in blood could be considered as a possible early diagnostic biomarker in breast cancer that is an urgent need for better management of cancer.</div>
AKAP4
, Diagnostic Biomarker,
Gene Expression
0
0
http://mcijournal.com/browse.php?a_code=A-10-33-9&slc_lang=en&sid=1
Motahareh
Sheikhhosseini
1003194753284600585
1003194753284600585
No
Mahdieh
Salimi
1003194753284600586
1003194753284600586
Yes