Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1396
7
1
gregorian
2017
10
1
1
Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress
online
1
fulltext
en
Cardiospermum Halicacabum Seeds: a Potential Human Breast Cancer Cell Lines Growth Inhibitors
Materials Science and Nanomedicine
Original/Research Article
<div style="text-align: justify;"><strong>Introduction:</strong> Among different types of medication for cancer, medicines of natural sources have been had proven significant effect on preventions and cure of cancer due to their lesser side effects in comparison with other therapies. Hence, based on traditional hypotheses Cardiospermum halicacabum Linn. Seeds cytotoxic activity investigated against various human breast cancer cell lines.<br>
<strong>Materials and Methods:</strong> Cardiospermum halicacabum seed powder extracted with various solvents and fractioned with column chromatography technique. Different types of human breast carcinoma cell lines, namely MCF-7, MDA-MB-231, MDA-MB-435 selected for this test. Their cytotoxicity investigated with Sulforhodamine B colorimetric (SRB) assay. Active samples subjected to analysis by Gas chromatography - mass spectrometry (GC-MS) to identify active anticancer compounds.<br>
<strong>Results:</strong> The study revealed the potential cytotoxic activity of C. Halicacabum Linn seeds. against MCF-7 breast cancer cell line with 50% growth inhibition value (GI50) of 12.8 μg/ml and cytotoxicity effect of fractions of seed against MCF-7 breast carcinoma with 50% growth inhibition value (GI50) of <10 μg/ml. The GC-MS analysis suggested the presence of active components that led to this result.<br>
<strong>Conclusions:</strong> The results proved the medicinal value of Cardiospermum halicacabum Linn. Seeds inhibition effect on MCF-7 cells as an active antineoplastic agent which may be used in cancer therapy researches.</div>
Breast Cancer, Cardiospermum Halicacabum, Growth Inhibition
0
0
http://mcijournal.com/browse.php?a_code=A-10-33-16&slc_lang=en&sid=1
Behzad
Mohaddesi
1003194753284600610
1003194753284600610
Yes
Ashvin
Dudhrejiya
1003194753284600611
1003194753284600611
No