Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1396
7
1
gregorian
2017
10
1
1
Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress
online
1
fulltext
en
A Comparison Between Malignant Breast Neoplasms Apoptosis and Benign Breast Neoplasms Under Influence of DNA Fragmentation
Materials Science and Nanomedicine
Original/Research Article
<div style="text-align: justify;"><strong>Introduction:</strong> Interrelationship of cells proliferation and apoptosis regulate homeostasis in normal tissues. Breast cancer development is mainly due to defective apoptosis pathway. Since there is a significant interrelationship between the ratio of apoptotic bodies to normal cells and breast cancer pathogenesis, we conducted this study to contrast malignant breast neoplasms apoptosis with benign breast neoplasms under the influence of DNA Fragmentation.<br>
<strong>Materials and Methods:</strong> Sixty patients entered this study. Its control group were their both benign neoplasms and normal cells. After DNA extraction, DNA fragmentation was carried out with DNA laddering assay. Apoptotic bodies were detected in 1% agarose gel electrophoresis.<br>
<strong>Results:</strong> Apoptotic bodies were detected in 83.3% of breast cancer samples. However, no sign of apoptosis was observed in control samples and the number of positive cases in malignant samples was significantly higher than benign samples (P< 0.05).<br>
<strong>Conclusions:</strong> It is revealed that the rate of apoptosis detectable by DNA fragmentation in malignant breast neoplasms is higher than benign types so that it can be used as a quick-diagnostic technique.</div>
DNA Fragmentation, Apoptosis, Breast Cancer, Benign, Malignant
0
0
http://mcijournal.com/browse.php?a_code=A-10-33-19&slc_lang=en&sid=1
Parisa
Derogar
10031947532846001344
10031947532846001344
No
Ali Akbar
Abolfathi
10031947532846001345
10031947532846001345
No
Asal
Safi Samghabadi
10031947532846001346
10031947532846001346
No
Afsaneh
Yazdani
10031947532846001347
10031947532846001347
No
Fateme
Afkhami
10031947532846001348
10031947532846001348
Yes