Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1396
7
1
gregorian
2017
10
1
1
Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress
online
1
fulltext
en
Relationship Between Folate and Vitamin B12 Levels and the Status of Estrogen Receptor Alpha (ERa) Hypermethylation in Patients with Breast Cancer in Iranian Women
Materials Science and Nanomedicine
Original/Research Article
<div style="text-align: justify;"><strong>Introduction:</strong> The genetic expression of Retinoic acid and Estrogen Receptor alpha (Era) for breast tumor cells has a therapeutic importance. Hypermethylation has been shown to play a key role in silencing the expression of these genes. The present review article aimed to determine the relationship between folate and vitamin B12 levels of plasma and the status of ERa hypermethylation in patients with breast cancer.<br>
<strong>Materials and Methods:</strong> This review was gathered from original and review studies publishedin Google scholar, Medline, PubMed and Science direct with key words of Estrogen-Receptor alpha gene, hypermethylation, breast cancer, folate, vitamin B12 between the years of 2000 to 2017.<br>
<strong>Results:</strong> Folate and vitamin B12 are as cofactories in metabolism and supply of single carbon units for the synthesis of SAM (S-adenosylmethionine) and methylation of many biological compounds, in regulation of genes expression, purine and pyrimidine synthesis, in the formation of chromosome stability and other reactions biochemicals. Therefore, their deficiency promotes the development of cancer by disrupting gene expression regulation. The findings of this study showed the reverse effect of folate and vitamin B12 plasma on the status of hypermethylation of ERa gene in patients with breast cancer. Significant correlation was found between these values and the risk of progression of gene hypermetylation. Despite the evidence that there is an inverse relationship between folate and vitamin B12 and the risk of breast cancer, the results of a number of studies contradicted these findings.<br>
<strong>Conclusions:</strong> It can therefore be concluded that the decrease in plasma folate and vitamin B12 levels and inadequate intake of them may play a role in the prognosis of hypermethylation of genes in breast cancer patients.</div>
Estrogen- Receptor Alpha Gene, Hypermethylation, Breast Cancer, Folate, Vitamin B12
0
0
http://mcijournal.com/browse.php?a_code=A-10-33-67&slc_lang=en&sid=1
Zahra
Bajalan
1003194753284600820
1003194753284600820
Yes
Farnoosh
Moafi
1003194753284600821
1003194753284600821
No
Somayeh
Falah
1003194753284600822
1003194753284600822
No
Faegheh
Golalizadeh Bibalan
1003194753284600823
1003194753284600823
No