Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1396
1
1
gregorian
2017
4
1
1
2
online
1
fulltext
en
The Applicability of the Gail Model in Iranian Population
Genetics
Original/Research Article
<p dir="ltr" style="font-style: normal; text-align: justify;"><strong>Introduction:</strong> Gail model is one of the most important models for the evaluation of breast cancer risk between US white females. According to genetic diversity, there is a possibility of affecting the efficiency of the Gail model in risk assessment of breast cancer among Iranian populations. In this study, the Gail model efficiency in specifying the risk of breast cancer in Iranian population was evaluated.<br>
<strong>Methods:</strong> This was a case-control study. The case group was formed of the referrals to Breast Cancer Research Center, Academic Center for Education Culture and Research (ACECR), who were affected by different types of aggressive cancer.<br>
<strong>Results:</strong> A total of 416 patients with breast cancer and the same number in the control group were considered during the study. There were no meaningful statistical differences in age at menarche, age at first live birth, and nulliparous women between case and control groups. The average of five-year risk of breast cancer in the case and control groups had no statistically significant difference. Chemoprevention was only eligible for 7.2% of the patients based on 1.67% five-year risk. In addition, there was no statistically meaningful difference between comparative risk and breast cancer risk in a lifetime.<br>
<strong>Conclusions:</strong> The low risks estimated by the Gail model among patients with breast cancer as well as the absence of meaningful statistical difference in the estimated risks by this model between the case and control groups showed that the Gail model had insufficient efficiency in determining breast cancer risk in the Iranian society.</p>
Breast Neoplasms, Risk Assessment, Iran.
13
19
http://mcijournal.com/browse.php?a_code=A-10-32-1&slc_lang=en&sid=1
Leila
Farahmand
laylafarahmand@gmail.com
10031947532846001198
10031947532846001198
No
Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
Mohammad Hossein
Shojamoradi
mh_shoja@yahoo.com
10031947532846001199
10031947532846001199
No
Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
Massoome
Najafi
mdmasoume@yahoo.com
10031947532846001200
10031947532846001200
No
Division of Surgical Oncology, Department of Surgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Keivan
Majidzadeh-A
kmajidzadeh@razi.tums.ac.ir
10031947532846001201
10031947532846001201
Yes
Genetics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran