en Supportive and Palliative Care Case Report and Series <div style="text-align: justify;"><span style="font-size:16px;"><span style="font-family:Times New Roman;"><strong>Int</strong><strong>r</strong><strong>oduction</strong><strong>: </strong>Extragenital tumors uncommonly affect the female genital tract and usually involve the ovaries (75-80%), while the uterus can harbor metastases in the context of a widely disseminated disease. The primary tumors are most often located in the breast (35%) or gastrointestinal tract (38%). Metastases to the uterine body usually involve the myometrium whereas those exclusively involving the endometrium are rare.<br> <strong>Cas</strong><strong>e presentation: </strong>We report the case of a 50-year-old woman with endometrial metastasis from a colonic adenocarcinoma 6 years after the initial presentation.<br> <strong>Conclusion</strong><strong>: </strong>Metastatic colon tumors can histologically present as a primary disease in the endometrium if the pathologist has little awareness to consider metastasis. The clinical history of disseminated metastases, the lack of CK7 expression at immunohistochemistry, and positive results for CK20 and nuclear CDX2 are helpful clues to support the diagnosis of metastatic carcinoma of colorectal origin.</span></span></div> Uterus, Neoplasm Metastasis, Endometrium, Colonic Neoplasms 1 4 http://mcijournal.com/browse.php?a_code=A-10-508-1&slc_lang=en&sid=1 Irene Pecorella irene.pecorella@uniroma1.it 10031947532846003096 10031947532846003096 Yes Department of Radiologic, Oncologic and Anatomic Pathology, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy Chiara Di Tucci chiara.ditucci@gmail.com 10031947532846003097 10031947532846003097 No Department of Maternity and Urological Sciences, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy Emma Rullo emma.rullo92@gmail.com 10031947532846003098 10031947532846003098 No Department of Radiologic, Oncologic and Anatomic Pathology, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy Hiba Wazeer Al Zou'bi Hibawazeer@yahoo.com 10031947532846003099 10031947532846003099 No Department of Radiologic, Oncologic and Anatomic Pathology, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy Ludovico Muzii ludovico.muzii@uniroma1.it 10031947532846003100 10031947532846003100 No Department of Maternity and Urological Sciences, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy