Multidisciplinary Cancer Investigation

en Morphogenetic Mechanisms of Endothelial Cells During Lumen Formation in Sprouting Angiogenesis Biomedical Engineering and Technologies Review Article <div style="text-align: justify;">Different mechanisms such as cell migration, proliferation, branching, anastomosis, and lumen formation occur during the angiogenesis process. Lumen formation is one of the critical mechanisms which is not only necessary for the functional plexus but also for continuing of angiogenesis process. Although multiple studies investigated this mechanism during the angiogenesis process in both in vivo and in vitro conditions, it is not fully understood yet. Different studies have suggested distinctive mechanisms as the main mechanism for lumen formation. Recent studies, however, have shown the fundamental role of blood flow hemodynamics, especially during in vivo lumen formation. This newly introduced mechanism is called ''inverse membrane blebbing''; suggesting that blood pressure causes the formation and expansion of lumen during the in vivo angiogenesis process. This paper reviews cell behavior during lumen formation in the angiogenesis process on a cellular scale.</div> Endothelial Cells, Blood Pressure, Neovascularization, Pathologic, Angiogenesis Inducing Agents 1 8 http://mcijournal.com/browse.php?a_code=A-10-523-1&slc_lang=en&sid=1 Mohammad Salar Ghasemi Nasab 10031947532846003337 10031947532846003337 No Department of Biomedical Engineering, Sahand University of Technology, Tabriz, Iran Hanieh Niroomand-Oscuii niroomand@sut.ac.ir 10031947532846003338 10031947532846003338 Yes Department of Biomedical Engineering, Sahand University of Technology, Ta- briz, Iran Hossein Bazmara 10031947532846003339 10031947532846003339 No Azad University, Pardis Branch, Tehran, Iran Majid Soltani 10031947532846003340 10031947532846003340 No Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran & Advanced Bioengineering Initiative Center, Computational Medicine Center, K. N. Toosi University of Technology, Tehran, Iran & Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran & Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, Ontario, Canada & Centre for Biotechnology and Bioengineering (CBB), University of Waterloo, Waterloo, Ontario, Canada