Multidisciplinary Cancer Investigation
نشریه بین المللی چند تخصصی سرطان
Multidiscip Cancer Investig
Medical Sciences
http://mcijournal.com
1
admin
2476-4922
2538-1911
10.30699/acadpub.mci
en
jalali
1401
4
1
gregorian
2022
7
1
6
3
online
1
fulltext
en
The Role of Helicobacter Pylori Virulence Factors in Gastric Cancer
Prevention, Early Detection and Screening
Review Article
<h1 style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><strong>Introduction:</strong> Gastrointestinal (GI) cancers are considered among the most important causes of mortality and morbidity. Helicobacter pylori infection has been proven to be highly associated with the development of a variety of gastric diseases such as chronic gastritis, peptic ulcer disease (PUD), mucosa-associated lymphoid tissue (MALT), and gastric cancer (GC). To date, the exact role of the virulence factors in gastric diseases and other diseases remains elusive and controversial.<br>
<strong>Methods:</strong> The present study is a classic systematic review (expert opinion), in which articles published in English and Persian languages derived from Web of Science, Scopus, PubMed, and Iranian databases, including Magiran, IranMede, and scientific information database (SID) without any time limitation were explored using standardized keywords of H. pylori, virulence factors, gastric cancer, a combination of the above words, and other synonymous keywords. Finally, the information and obtained results were collected and interpreted.<br>
<strong>Results:</strong> In total, 14 of the 172 articles reviewed had inclusion criteria with the approval of the responsible author. According to the results, the development of chronic bacterial inflammation due to pathogenic mechanisms and factors, especially the role of cagA and vacA genes in gastric cancer, remains an important medical problem.<br>
<strong>Conclusions:</strong> Each of the H. pylori virulence factors can have a role in cancer development, and it appears that on-time H. pylori treatment is one of the best methods to prevent gastric cancer. Therefore, targeting Pathogenic factors of H. pylori to induce apoptosis and stimulate the immune system will be a promising, attractive, and helpful method for cancer prevention.</span></span></h1>
Stomach Neoplasms, Helicobacter pylori, Virulence Factors, Iran
1
7
http://mcijournal.com/browse.php?a_code=A-10-598-1&slc_lang=en&sid=1
Abbas
Ganjali
10031947532846003456
10031947532846003456
No
Department of Plant Breeding and Biotechnology, Faculty of Agriculture, , University of Zabol, Zabol, Iran
Barat ali
fakheri
fakheri@uoz.ac.ir
10031947532846003457
10031947532846003457
No
Department of Plant Breeding and Biotechnology, Faculty of Agriculture, University of Zabol, Zabol, Iran
Abbas
Bahari
bahari@znu.ac.ir
10031947532846003458
10031947532846003458
Yes
Department of Biotechnology, Research Institue of Modern Biological Techniques, University of Zanjan, Zanjan, Iran
leila
fahmideh
10031947532846003459
10031947532846003459
No
Department of Plant Breeding and Biotechnology, Gorgan University of Agriculture Sciences and Natural Resources, Gorgan, Iran
reza
valadan
10031947532846003460
10031947532846003460
No
Department of Immunology, Molecular and Cell Biology Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran