en Biomedical Engineering and Technologies Original/Research Article <div style="text-align: justify;"><span style="font-size:16px;"><span new="" roman="" style="font-family:" times=""><span class="A3" style="color:#221e1f"><b>Introduction: </b></span><span class="A3" style="color:#221e1f">Bone metastases are one of the most important consequences of breast cancer, and the possibility of developing them is greatly increased due to the late diagnosis of the cancer. In general, systemic treatments for metastases can have many side effects. To reduce this concern, tissue engineering scaffolds containing osteogenesis drugs can be used to minimize these problems as much as possible. </span><span style="color:#221e1f"></span></span><br> <span new="" roman="" style="font-family:" times=""><span class="A3" style="color:#221e1f"><b>Methods: </b></span><span class="A3" style="color:#221e1f">In this study, polycaprolactone/polyvinyl alcohol (PCL/PVA) composite scaffolds were prepared for use in bone tissue engineering with a weight percentage of strontium ranelate (SrR) drug (0, 5, and 20) by shell-core emulsion electrospinning method. Scaffolds prepared in this study were subjected to scanning electron microscopy (SEM), contact angle, and biodegradation analyses for morphological and structural investigation. Then, to check their biocompatibility, an MTT test was performed. </span><span style="color:#221e1f"></span></span><br> <span new="" roman="" style="font-family:" times=""><span class="A3" style="color:#221e1f"><b>Results: </b></span><span class="A3" style="color:#221e1f">The results of SEM images showed the nanostructure of the fibers. Also, the presence of interconnected pores with a suitable size was confirmed by the images. MTT results proved the non-toxicity of all prepared scaffolds by high cell viability (˃80%). According to the obtained results, the composite scaffolds containing the drug SrR have been successfully synthesized and have the desired properties for use in bone regeneration applications. </span><span style="color:#221e1f"></span></span><br> <span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span class="A3" style="color:#221e1f"><b><span style="line-height:115%">Conclusion: </span></b></span><span class="A3" style="color:#221e1f"><span style="line-height:115%">Controlling bone metastases due to breast cancer is an important concern. In this study, the composite scaffold containing strontium ranlate showed suitable physicochemical, biocompatibility, and osteogenesis characteristics.</span></span></span></span></span></div> Breast Neoplasms, Metastasis, Tissue Engineering, Drug Delivery System 21 27 http://mcijournal.com/browse.php?a_code=A-10-687-1&slc_lang=en&sid=1 Seyyed Behnam Abdollahi Boraei be.abdollahi@ut.ac.ir 10031947532846003968 10031947532846003968 Yes Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran Zanyar Pirkani Zanyar.Pirkani@gmail.com 10031947532846003969 0009-0007-3378-8462 No Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran J.Jhamak Nourmohammadi J_Nourmohammadi@ut.ac.ir 10031947532846003970 10031947532846003970 No Faculty of Life Science Engineering, Faculties of Sciences and Interdisciplinary Technologies, University of Tehran, Tehran, Iran behnaz Abdollahi Boraei B.bakhshandeh@ut.ac.ir 10031947532846003971 10031947532846003971 No Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran Mohammad Mehdi Dehghan m.dehghan@ut.ac.ir 10031947532846003972 10031947532846003972 No Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Mehdi Rahmanian mrahmanian1@gmail.com 10031947532846003973 10031947532846003973 No Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran