en Molecular Mechanisms Review Article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:120%"><span new="" roman="" style="font-family:" times=""><span style="font-size:10.5pt"><span style="line-height:120%"><span style="color:#231f20">Oncometabolites such as L-lactate, succinate, fumarate, R-2-hydroxyglutarate, kynurenine, and itaconate are emerging as pivotal drivers of cancer progression. Beyond their metabolic roles, these molecules function as signaling mediators that remodel epigenetic landscapes, reprogram the tumor microenvironment, and promote immune evasion. This review synthesizes current insights into their biochemical origins, oncogenic mechanisms, and therapeutic potential, highlighting how targeting oncometabolite-driven pathways could facilitate the development of novel cancer therapies.</span></span></span><span style="font-size:10.5pt"><span style="line-height:120%"></span></span></span></span></span></div> Oncometabolites, L-lactate, Succinate, Fumarate, R-2-Hydroxyglutarate, Kynurenine, Iltaconate Fumarate,Iltaconate,Kynurenine,L-lactate,Oncometabolites,R-2-Hydroxyglutarate,Succinate, 31 46 http://mcijournal.com/browse.php?a_code=A-10-721-1&slc_lang=en&sid=1 Zahra Sheikhi 10031947532846004245 10031947532846004245 No Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran Mohtaram Vafakhah 10031947532846004246 10031947532846004246 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Hamed Mirzaei 10031947532846004247 10031947532846004247 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Mahdieh Khosravi 10031947532846004248 10031947532846004248 No Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Kambiz Gilany k.gilany@avicenna.ac.ir 10031947532846004249 10031947532846004249 Yes Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran