en
jalali
1400
4
1
gregorian
2021
7
1
5
3
online
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fulltext
en
Dosimetry Impact of Boron and Its Carriers Structure at Boron Neutron Capture Therapy of a Brain Tumor; A Sim- ulation Study
Introduction: Boron neutron capture therapy (BNCT) is a method of cancer treatment and potentially, two borono-L-phenylalanine (BPA) and sodium borocaptate (BSH) are used in BNCT as common boron carriers. Some previous studies have shown that the dose rate is directly related to boron concentration in the tissue. This study aimed to simulate the structure of boron carriers and brain tumor compounds according to the real clinical condition. Moreover, the effect of carrier concentration in tumor volume and boron concentration in carriers' structure would be numerically assessed.
Methods: First, a phantom is developed by FLUKAsimulation code to perform dosimetry aspects of Boron and carriers on a typical brain tumor. Moreover, the components of carriers were then simulated separately and the dosimetry parameters were assessed by changing the amount of boron in the carriers’ structure and by the carriers' concentration variations inside and around the tumor to mimic the real condition.
Results: The results showed that by increasing boron inside the BPA structure from 5.17% to 50%, the dose will be increased up to 78.46%. In the BSH, tumor dose is raised to 9.06% by increasing the amount of boron concentration at carrier structure from 59% to 80%. Moreover, by enhancing the two carriers' concentration inside the tumor volume up to 30%, the dose value is increased up to 9.59% and 3.20% for BPA and BSH carriers, respectively.
Conclusions: The level of boron in the carrier's structure and also carriers' concentration is highly remarkable on dose delivery inside tumor volume and surrounding tissues.
Boron Neutron Capture, Therapy, Boron, Drug Carriers, Radiation Dosage, Monte Carlo Method
1
7
http://mcijournal.com/browse.php?a_code=A-10-479-1&slc_lang=en&sid=1
2020/11/10
1399/8/20
2021/05/16
1400/2/26
Abbas
Imani Pourya
Faculty of Sciences and Modern Technologies, Graduate University of Ad- vanced Technology, Kerman, Iran
abbasimanipourya@gmail.com
0031947532846003035
0031947532846003035
No
Ahmad
Esmaili Torshabi
Faculty of Sciences and Modern Technologies, Graduate University of Ad- vanced Technology, Kerman, Iran
a.esmaili@kgut.ac.ir
0031947532846003036
0031947532846003036
Yes
en
The Efficacy and Safety of Iodine-125 Implantation Combined with Gemcitabine in the Treatment of Advanced Pan- creatic Cancer: A Systematic Review and Meta-analysis
Introduction: A systematic review and meta-analysis was conducted to assess the efficacy and safety of iodine-125 implantation combined with gemcitabine in the treatment of advanced pancreatic cancer.
Methods: PubMed, Chinese National Knowledge Infrastructure database (CNKI), Cochrane Library, Embase, and Wanfang database through Oct 2020 were searched
for randomized controlled trials (RCTs) and retrospective studies assessing the efficacy
and safety of iodine-125 implantation combined with gemcitabine in the treatment of advanced pancreatic cancer. The main outcome measures included the overall remission [complete response (CR)+partial response (PR)] rate, overall survival (OS), hypofunction of the liver, clinical benefit response (CBR) rate, survival rate, and adverse events.
Results: Totally, 19 studies involving 1496 patients were included in the current systematic review and meta-analysis. The pooled results showed that efficacy and safety of patients treated with Iodine-125 combined with gemcitabine were superior to those undergoing gemcitabine alone: overall remission (CR+PR) rate [odds ratio (OR)=3.10, 95% confidence interval (CI): 2.40, 4.00; P<0.00001], OS [hazard ratio (HR)=0.56, 95% CI: 0.47, 0.68; P<0.00001], hypofunction of liver (OR=1.08, 95% CI: 0.67, 1.74;
P=0.75), CBR rate (OR=3.85, 95% CI: 2.83, 5.22; P<0.00001), survival rate of six months (OR=3.44 95% CI: 1.83, 6.46) and survival rate of 12 months (OR=2.67, 95% CI: 1.68, 4.26). And there was no statistical association in adverse events between the groups.
Conclusions: The combination of iodine-125 seed implantation and gemcitabine significantly prolonged the survival of patients with pancreatic cancer, compared with the gemcitabine alone, indicating a better prognosis.
Iodine-125, Pancreatic Neoplasms, Meta-Analysis, Gemcitabine
1
12
http://mcijournal.com/browse.php?a_code=A-10-500-2&slc_lang=en&sid=1
2020/11/102021/02/28
1399/12/10
2021/05/162021/06/15
1400/3/25
Jingxin
Yan
Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China & Department of Postgraduate, Qinghai University, Xining, China
583720460@qq.com
0031947532846003043
0031947532846003043
Yes
Ting
Li
Department of Orthopedics, Sichuan People's Hospital, Chengdu, China & Department of Postgraduate, Chengdu Medical College, Chengdu, China
1215946762@qq.com
0031947532846003044
0031947532846003044
No
Yaxuan
Wang
Department of Radiology, Chengdu Medical College, Chengdu, China
1627608691@qq.com
0031947532846003045
0031947532846003045
No
Hao
Zhu
Department of Ultrasound Medicine, People’s Hospital of Tibet Autonomous Region, Lhasa, China ; Department of Postgraduate, Tibet University, Lhasa, China
675050874@qq.com
0031947532846003047
0031947532846003047
No
Ruihong
Liu
Nanchong Central Hospital, North Sichuan Medical College, Nanchong, China
949495231@qq,com
0031947532846003048
0031947532846003048
No
Zhenwu
Lei
Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China
qhdxzhenwulei@foxmail.com
0031947532846003049
0031947532846003049
No
Yingxing
Guo
Department of Interventional Therapy, Affiliated hospital of Qinghai University, Xining, China
guoyingxing1962@qq.com
0031947532846003046
0031947532846003046
No
en
Endometrium-limited Metastasis From Colon Carcinoma
Introduction: Extragenital tumors uncommonly affect the female genital tract and usually involve the ovaries (75-80%), while the uterus can harbor metastases in the context of a widely disseminated disease. The primary tumors are most often located in the breast (35%) or gastrointestinal tract (38%). Metastases to the uterine body usually involve the myometrium whereas those exclusively involving the endometrium are rare.
Case presentation: We report the case of a 50-year-old woman with endometrial metastasis from a colonic adenocarcinoma 6 years after the initial presentation.
Conclusion: Metastatic colon tumors can histologically present as a primary disease in the endometrium if the pathologist has little awareness to consider metastasis. The clinical history of disseminated metastases, the lack of CK7 expression at immunohistochemistry, and positive results for CK20 and nuclear CDX2 are helpful clues to support the diagnosis of metastatic carcinoma of colorectal origin.
Uterus, Neoplasm Metastasis, Endometrium, Colonic Neoplasms
1
4
http://mcijournal.com/browse.php?a_code=A-10-508-1&slc_lang=en&sid=1
2020/11/102021/02/282021/03/16
1399/12/26
2021/05/162021/06/152021/07/10
1400/4/19
Irene
Pecorella
Department of Radiologic, Oncologic and Anatomic Pathology, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy
irene.pecorella@uniroma1.it
0031947532846003096
0031947532846003096
Yes
Chiara
Di Tucci
Department of Maternity and Urological Sciences, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy
chiara.ditucci@gmail.com
0031947532846003097
0031947532846003097
No
Emma
Rullo
Department of Radiologic, Oncologic and Anatomic Pathology, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy
emma.rullo92@gmail.com
0031947532846003098
0031947532846003098
No
Hiba
Wazeer Al Zou'bi
Department of Radiologic, Oncologic and Anatomic Pathology, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy
Hibawazeer@yahoo.com
0031947532846003099
0031947532846003099
No
Ludovico
Muzii
Department of Maternity and Urological Sciences, University of Rome “La Sapienza”, Viale Regina Elena, Rome, Italy
ludovico.muzii@uniroma1.it
0031947532846003100
0031947532846003100
No
en
Biosynthesis of Silver Nanoparticles Using Hydroethanolic Extract of Cucurbita pepo L. Fruit and Their Anti-proliferative and Apoptotic Activity Against Breast Cancer Cell Line (MCF-7)
Introduction: Cancer is the second leading cause of death all over the world and breast cancer is the second common member of cancers worldwide. In this study, silver nanoparticles (Ag-NPs) were synthesized; using hydroethanolic extract of Cucurbita pepo
L. fruit and evaluated for their antiproliferative and apoptotic activities against MCF-7 cell line.
Methods: Ag-NPs formation was characterized by ultraviolet-visible spectroscopy, energy dispersive spectroscopy (EDX), scanning electron microscopy (SEM), dynamic light scattering (DLS), and Fourier transform infrared (FTIR) spectroscopy. Cytotoxicity and apoptosis responses were evaluated by 3-[4,5-dimethylthiazole-2-yl]-2,5- diphenyltetrazolium bromide (MTT) and dual acridine orange/ethidium bromide (AO/ EB) fluorescent staining, respectively.
Results: Our results demonstrated the formation of Ag-NPs by Cucurbita pepo L. fruit extract discoloration to dark black. This transformation revealed their slightly aggregated shapes to quasi-spherical form with a mean diameter of 104 nm. The zeta potential value was -42.3 mV for any Ag-NPs. These results indicated the successful formation of Ag- NPs for cellular uptake. MTT results showed that Ag-NPs significantly decreased the viability and induced MCF-7 cells apoptosis in a dose-dependent manner; especially at concentrations of 50 and 250 μg/mL.
Conclusions: In conclusion, according to the results of the present study, biologically synthesized Ag-NPs induce apoptotic and cytotoxic effects against breast cancer cell lines in a dose-dependent manner.
Cell Line, Breast Neoplasms, Nanoparticles, Green Chemistry Technology, Cucurbita
1
10
http://mcijournal.com/browse.php?a_code=A-10-525-1&slc_lang=en&sid=1
2020/11/102021/02/282021/03/162021/05/19
1400/2/29
2021/05/162021/06/152021/07/102021/07/17
1400/4/26
Leila
Soltani
Department of Animal Sciences, College of Agriculture and Natural Resources, Razi University, Kermanshah, Iran
leilasoltani7@yahoo.com
0031947532846003093
0031947532846003093
Yes
Maryam
Darbemamieh
Department of Plant Protection, College of Agriculture and Natural Resources, Razi University, Kermanshah, Iran
darbemamieh@gmail.com
0031947532846003094
0031947532846003094
No
en
The Effect of Pilates Training on Changes in Hematological Parameters in Women With Breast Cancer
Introduction: One of the major side effects of chemotherapy is blood cell density reduction and changes in the immune system. The benefi of exercise interventions have been reported for cancer patients. This study aimed to investigate the effect of Pilates training on changes in hematological parameters in women with breast cancer.
Methods: In this randomized controlled trial, 24 women with breast cancer who were referred to health centers therapy and private clinics of Shiraz were selected and divided into two groups: Pilates training and control. The Pilates training group performed exercises for 10 weeks. Each week was compromised of 3 sessions; lasting 60 minutes. The control group performed only their daily activities during this period. Blood sampling and anthropometric measurements were performed before and after the training period. Data were analyzed by independent and dependent t-test.
Results: The results showed that 10 weeks of Pilates training had no signifi effect on weight, body mass index, and waist to hip ratio in women with breast cancer. Pilates training had no signifi effect on white blood cell count, red blood cells (mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration), hemoglobin, hematocrit, and platelets in women with breast cancer.
Conclusions: It seems that more research is needed to investigate the effects of this type of exercise to achieve their benefi changes in hematological parameters and the immune system.
Breast Neoplasms, Hematocrit, Exercise Movement Techniques, Blood Platelets, Erythrocytes, Leukocytes
1
8
http://mcijournal.com/browse.php?a_code=A-10-498-1&slc_lang=en&sid=1
2020/11/102021/02/282021/03/162021/05/192021/03/1
1399/12/11
2021/05/162021/06/152021/07/102021/07/172021/08/25
1400/6/3
Saeedeh
Shadmehri
Department of Physical Education and Sport Sciences, Yadegar-e-Imam Khomeini (RAH) Shahr-e-Ray Branch, Islamic Azad University, Tehran, Iran
saeedehsh61@gmail.com
1062889258
0031947532846003137
No
Nasibe
Kazemi
Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
nasibe.kazemi@yahoo.com
0031947532846003138
0031947532846003138
Yes