Breast Cancer Recearch Center, ACECR
Multidisciplinary Cancer Investigation
2476-4922
1
3
2017
7
1
The Role of Microgravity in Cancer: A Dual-edge Sword
1
5
EN
Reza
Sahebi
Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Maryam
Aghaei
Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Sina
Halvaei
School of Biology, College of Science, University of Tehran, Tehran, Iran
Akram
Alizadeh
Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Since human beings could travel beyond the earth atmosphere, scientists started to investigate the effect of microgravity on human cells. Microgravity has different effects on normal and cancer cells, but the related mechanisms are not well-known till now. The aim of the present review is to focus on the consequences of exposing the cancer cells to reduced gravity. Some cancer cells organize three-dimensional structures under microgravity.
Obviously, microgravity is an external stress, which can affect cell proliferation, apoptosis, cytoskeleton and signaling pathways. In addition, it touches immune-related components, regulates immune responses, and implicates immune cell activation. Low mutation aggregation and cancer rate in astronauts may lead to use microgravity as a therapeutic approach. However, it reduces the invasion and migration in some types of cancer cells, triggers the oncogenic signaling pathways including KRAS, and inhibits proliferation in normal lymphocytes. In conclusion, using microgravity as a therapeutic method in cancer treatment needs to be more investigated on both cancer and normal cells, and might not become true in the near future.
Breast Cancer Recearch Center, ACECR
Multidisciplinary Cancer Investigation
2476-4922
1
3
2017
7
1
Cancer metastasis at a glance: A brief view of Breast Cancer Brain Metastasis
6
9
EN
Parvin
Mehdipour
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes.
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Breast Cancer Recearch Center, ACECR
Multidisciplinary Cancer Investigation
2476-4922
1
3
2017
7
1
Molecular Identification, Isolation and Evaluation of Persian Gulf Actinomycetes as Candidates of Cytotoxic Metabolites Against Breast Cancer
10
14
EN
Aref
Bahri
Department of Microbiology, Faculty of Science, Agriculture and new technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Elham
Moazamian
Department of Microbiology, Faculty of Science, Agriculture and new technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran (Ph.D.)
Negar
Azarpira
Professor, Organ Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. (Ph.D.)
Introduction: Marine actinomycetes have a great potential to produce unique bioactive compounds due to their special adaptation in the harsh ocean environment. The current study aimed to isolate anti-cancer compounds producing actinomycetes from sediments of Harra forests of the Persian Gulf and investigate their potential as anti-breast cancer metabolites.
Methods: In the current study, 40 sediment samples of Harra forests of the Persian Gulf were collected. Samples were diluted and cultured in a starch casein agar selective medium. The strains were isolated and purified, using morphological and microscopic methods. Forty strains were cultured in a starch casein broth and the metabolites were extracted using ethyl acetate. The produced metabolites were extracted from active strains and their cytocidal activities were evaluated against the breast cancer cell line. Finally, effective-metabolites-producing bacteria were identified using the molecular method.
Results: Of the sediments, 186 strains were isolated and identified. Results showed that the isolates had cytocidal activities against the breast cancer cell line. The results also revealed that the 2HP and 4HP strains showed more anti-cancer activities than the others. Results of this study showed that sediments of Harra forests of the Persian Gulf were rich in active actinomycetes, which can be used in the production of new anticancer compounds.
Conclusions: The obtained results give evidence that it is essential to scrutinize these marine microorganisms, which have a great potential to be used in the pharmaceutical fields, in search for new drugs.
Breast Cancer Recearch Center, ACECR
Multidisciplinary Cancer Investigation
2476-4922
1
3
2017
7
1
Mothers and Sisters are the Most Effective Sources of Support in Coping with Disease in Patients with Breast Cancer
15
21
EN
Maryam
Koosha
Prevention Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR , Tehran, Iran
Azam
Raoofi
Medical Ethics Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR , Tehran, Iran
Alireza
Bahrami
Prevention Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR , Tehran, Iran
Akram
Sajadian
Quality of life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR , Tehran, Iran
Hoda
Tafazzoli-Harandi
Prevention Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR , Tehran, Iran
Shahpar
Haghighat
Quality of life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR , Tehran, Iran
Introduction: Breast cancer could adversely affect the self-esteem of women, family performance, sexual role, and quality of life. Sources of support are considered as one of the most effective coping strategies against problems and consequences of breast cancer. The current study aimed at evaluating different supportive sources and their impact on coping behavior of patients with breast cancer.
Methods: The current descriptive, analytic, cross-sectional study included 100 patients with breast cancer. The instruments consisted of a questionnaire designed to measure the sources of support and another questionnaire on coping behavior with the disease. The data were
analyzed by the Pearson correlation, linear regression, and descriptive statistics (mean and standard deviation) with SPSS version 14.
Results: The mean age of the patients was 45.59 ± 9.1 years. Overall, 69% of the study subjects were married and 77% were housewives. There was a positive and significant correlation between the received supportive sources and the disease coping behavior (P=0.049). In addition, the mean score of supportive source received from mothers and sisters was the highest in women with breast cancer (3.86).
Conclusions: Results of the current study indicated that women with breast cancer had the highest rate of coping behavior when their mothers and sisters supported them. This emphasizes the importance of required advice for all sources of support available for patients; therefore, the patients with breast cancer could deal with their disease more desirably.
Breast Cancer Recearch Center, ACECR
Multidisciplinary Cancer Investigation
2476-4922
1
3
2017
7
1
Breast Cancer or a Rear Diagnosis
22
24
EN
Toktam
Beheshtian
Breast Diseases Department, Breast Cancer Research Center, ACECR, Tehran, Iran
Faeze
Yahyaei
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Shahin
Ghassemi
Department of Infectious Diseases, Iran University of medical sciences, Tehran, Iran
Introduction: Tuberculosis (TB) and its diagnosis are of great importance in the middleeast, according to the increasing burden of this disease and the large number of unreported cases. Less than 20% of all TB cases only have extra-pulmonary manifestations and breast TB is a rare form of extra-pulmonary TB. It includes about 1% of all breast lesions.
Case Presentation: This study presents a breast TB case, which was an 83 year-old woman who that complained of fatigue, lethargy, and fever. In the physical examination, the patient had a discharging abscess in upper outer quadrant of her right breast associated with edema and erythema, accompanied with multiple axillary and supraclavicular adenopathies. Imaging showed multiple cervical, axillary, and abdominal adenopathies.
Clinical manifestations were highly suggestive of inflammatory breast carcinoma. Further investigations, including lymph node biopsy and Polymerase Chain Reaction (PCR) helped with the diagnosis of TB in the patient. The patient was treated with quadruple
therapy of TB.
Discussion: Because of its nonspecific clinical features, TB mastitis is often being misdiagnosed and underreported. Early diagnosis of breast TB could reduce patients' morbidity and also facilitate an effective treatment of patients with inflammatory breast lesions. TB should be the first differential diagnosis of granulomatous mastitis.
Breast Cancer Recearch Center, ACECR
Multidisciplinary Cancer Investigation
2476-4922
1
3
2017
7
1
Building Trust Between Patients and Physicians
25
26
EN
Azita
Mazinani
Breast Cancer Research Center, ACECR, Tehran, Iran
mandana
Motamedi
Breast Cancer Research Center, ACECR, Tehran, Iran
Repairing and enhancing patient wellbeing are considered the most significant goals in the health sector. It is observed that a trustful relationship between physicians and other medical team members on one side and the patients and their families on the other side is really important to achieve the fundamental purposes in the “Art of Medicine”....