1 2476-4922 Breast Cancer Recearch Center, ACECR 333 Health Policy and Economics Incidental Pulmonary Embolism in Cancer Patients: A Single-Institution Analysis in Panama Sinclair De Frías Jorge b Cukier Moises c Olivero Lorenzo d Vazquez Daniella e Tapia Hector f b Faculty of Medicine, University of Panama, Panama City, Panama c Faculty of Medicine, University of Panama, Panama City, Panama & Department of Surgical Oncology, National Institute of Oncology, Panama City, Panama d Faculty of Medicine, University of Panama, Panama City, Panama e Faculty of Medicine, University of Panama, Panama City, Panama f Department of Radiology, National Institute of Oncology, Panama City, Panama 1 3 2022 6 1 1 7 11 08 2021 13 02 2022 Introduction: Incidental pulmonary embolisms (iPE) are common in cancer patients. Studies addressing iPE in oncology are increasing; however, few of these investigations have been conducted in a Latin-American population. This study aims to describe the incidence and characteristics of iPE in cancer patients in a comprehensive cancer center from Panama. Methods: A single-center, retrospective study was conducted at the National Institute of Oncology during a period of 7 months. Every contrast-enhanced CT scan was reviewed. Electronic records and CT reports were reviewed for demographic, clinical, and radiological information. Results: We reported 46 iPEs in 4065 scans (incidence=1.13%). The mean±SD age was 6413± years. Most patients were female (63.0%) and were outpatients (73.9%) when the CT scan was performed. Central iPEs were found in thirty-one patients (67.4%). Thirty patients were receiving chemotherapy (54.3%) or hormone therapy (10.9%); two-thirds had metastatic disease. The most frequently reported tumors were gastrointestinal, breast, and gynecologic cancers. More than 70% were reported as asymptomatic, and 78% were initially managed with anticoagulation. Conclusions: Our study reported a low incidence of iPE in oncologic patients (1.13%) which is consistent with what has been observed in previous studies (0.34%-7.3%). The true incidence is still uncertain, and it might be underestimated; especially the rate of subsegmental embolism.
348 Effects of 1Hz 100mT electromagnetic field on apoptosis induction and Bax/Bcl-2 expression ratio in breast cancer cells Moori Maryam g Norouzian Dariush h Yaghmaei Parichehr i Farahmand Leila j g Department of Biology, Science and Research Branch, Islamic Azad Univer- sity, Tehran, Iran h Pilot Nanobiotechnology Department, Pasteur Institute of Iran, Tehran, Iran i Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran j 3Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran 1 3 2022 6 1 1 7 17 12 2021 20 02 2022 Introduction: Breast cancer is the most common metastatic malignancy and the second leading cause of death in women. Recently, extremely low-frequency electromagnetic fields (ELF-EMFs) seem to modulate the rate of proliferation and enhance apoptosis and are considered as an emerging approach to cancer therapy. Despite recent success in the electromagnetic fields, the results are still neither definitive nor even contradictory.   Methods: In this study, induction of apoptosis was considered as one of the possible mechanisms of ELF-EMFs on cancer inhibition. Breast cancer cell lines were exposed to a 1 Hz, 100mT ELF-EMF (2h/day) for five days. the apoptosis rare of both the exposure and sham exposure groups was determined by flow cytometry. The expression levels of Bax and Bcl-2 were evaluated by real-time PCR. Results: The mRNA expression levels of Bax were increased; while the expression of Bcl-2 showed a decrease in MDA-MB231 cells exposed to 1Hz EMF compared with sham exposure. Moreover, the ratio of Bax/Bcl2 was significantly increased in comparison to the sham exposure. The increased Bax/Bcl-2 ratio induces cell apoptosis. Conclusions: It is suggested that ELF-EMF is a new adjuvant therapeutical method that may contribute to anti-cancer and cancer therapy research. 343 Supportive and Palliative Care Primary Cervical Non-Hodgkin Lymphoma; A Narrative Review Mousavi Seresht Leila k Ghobadi Shamin l k Obstetrics and Gynecology Department, Isfahan Medical Science School, Isfahan, Iran l Obstetrics and Gynecology Department, Isfahan Medical Science School, Isfahan, Iran 1 3 2022 6 1 1 3 17 10 2021 22 02 2022 Gynecological lymphoma is one of the rarest tumors of the female organs that need to be kept in mind in a suspected patient due to its different management protocol. Even though the reported cases of ovarian lymphoma are not limited; our knowledge about diagnosis and treatment of primary cervical lymphoma is restricted. There is a rising number of suggested imaging and pathological criteria that need precise analysis to confirm their benefits in achieving the appropriate outcome. Here, we aim to review the most relevant recent works about primary cervical non-Hodgkin lymphoma of the cervix as the most common type of this rare entity. 330 Genetics Monitoring of Adrenal Functions Amid the COVID-19 Pandemic: Lessons From Pediatric Leukemia Khater Doaa m Al-Yaarubi Saif n Al Dhawi Naji o Ullah Irfan p Saad Ashraf Al Obaidani Marwa Al Subhi Taimoora Wali Yasser Elshinawy Mohamed m Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman & Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt n Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman o Oman Medical Specialty Board, Oman p Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman Hematology Department, Sultan Qaboos University Hospital, Muscat, Oman Royal College of Surgeons, Dublin, Ireland Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman & Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman & Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt 1 3 2022 6 1 1 6 07 08 2021 22 02 2022 Introduction: Glucocorticoids are considered the cornerstone of the induction phase in all treatment protocols of acute lymphoblastic leukemia (ALL). Among the adverse effects of high-dose glucocorticoid treatment, adrenal insufficiency is secondary to suppression of the hypothalamic-pituitary-adrenal (HPA) axis. This drawback of exogenous steroid therapy gains a contemporary particular relevance in the current era of the COVID-19 pandemic. Methods: Thirty-two patients with ALL were recruited to participate in this study. Basal cortisol and adrenocorticotropic hormone (ACTH) levels were assessed before induction therapy and re-measured 7 days after steroid cessation. Patients with low cortisol levels were subjected to ACTH stimulation test and were followed up till recovery of ACTH axis. Results: There was a significant decline in the cortisol levels after completion of glucocorticoids therapy in eight patients (25%), (P<0.000) and it returned to normal levels at the 28th post-induction day (P<0.614). However, two patients showed no response to ACTH testing and received replacement physiologic doses of daily hydrocortisone. A patient had febrile neutropenia and another one developed COVID-19 pneumonia, for both of them high-stress steroid doses have been administered. All the studied patients had normal cortisol levels at the end of the 4-week follow-up period. Conclusions: We concluded that there might be a beneficial role of testing adrenal reserve in children with ALL; especially those at the maximum period of adrenal suppression. We highly recommend educating patients and families about early symptoms of adrenal insufficiency, assessing adrenocortical functions during the era of the COVID-19 pandemic, and implementing a prompt replacement therapy plan in order to avoid the catastrophic COVID-19-induced cytokine storm.