Multidisciplinary Cancer Investigation
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Volume 1 - Supplement Issue 1: Abstracts of International Tehran Breast Cancer Congress
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Emadi S, Azamian Jazi A, Hemmati S. Effect of Six Weeks of Moderate-intensity Aerobic Exercise on Lipid Peroxidation and Antioxidant Status of Women Survived of Breast Cancer. Multidiscip Cancer Investig 2017; 1
URL: http://mcijournal.com/article-1-148-en.html
URL: http://mcijournal.com/article-1-148-en.html
Abstract: (4936 Views)
Introduction: Oxidative damage is one of the known mechanisms of progression and recurrence
of breast cancer during disease process, radiotherapy and chemotherapy courses,
taking anti-cancer drugs and the loss of aerobic fitness. Therefore, the purpose of this study
was to investigate the effect of six weeks of moderate-intensity aerobic exercise on lipid
peroxidation and antioxidant status of women survived of breast cancer.
Materials and Methods: In this semi experimental study, 19 women survived of breast
cancer with mean age (45.26 ± 2.87 years) and BMI (26.35 ± 2.37 kg/m2) were selected
based on inclusion criteria and then were randomly divided into two control (n = 10)
and experimental (n = 9) groups. Experimental group performed three sessions of aerobic
training at 60-70 HRmax each week and for 6 weeks. The first week trainings, ranging from
60 to 65 HRmax, were conducted, until the end of the fifth week achieved to about 70
HRmax, and at sixth week continued with the same intensity. The control group did not
participate in any exercise program during this period. Blood sampling was conducted 24
hours before the first session and 48 hours after the end of the last training session. The
serum total antioxidant capacity (TAOC) and malondialdehyde (MDA) was measured by
ELISA kits. Data were analyzed by the use of dependent and independent t-test.
Results: A significant reduction in serum levels of MDA and a significant increase in
TAOC was observed in the experimental group (P = 0.003, P = 0.001).Aerobic fitness
improved significantly also (P = 0.001).
Conclusions: Regular moderate-intensity aerobic exercise can prevent the recurrence of
breast cancer by improving the body’s antioxidant defense and aerobic fitness.
of breast cancer during disease process, radiotherapy and chemotherapy courses,
taking anti-cancer drugs and the loss of aerobic fitness. Therefore, the purpose of this study
was to investigate the effect of six weeks of moderate-intensity aerobic exercise on lipid
peroxidation and antioxidant status of women survived of breast cancer.
Materials and Methods: In this semi experimental study, 19 women survived of breast
cancer with mean age (45.26 ± 2.87 years) and BMI (26.35 ± 2.37 kg/m2) were selected
based on inclusion criteria and then were randomly divided into two control (n = 10)
and experimental (n = 9) groups. Experimental group performed three sessions of aerobic
training at 60-70 HRmax each week and for 6 weeks. The first week trainings, ranging from
60 to 65 HRmax, were conducted, until the end of the fifth week achieved to about 70
HRmax, and at sixth week continued with the same intensity. The control group did not
participate in any exercise program during this period. Blood sampling was conducted 24
hours before the first session and 48 hours after the end of the last training session. The
serum total antioxidant capacity (TAOC) and malondialdehyde (MDA) was measured by
ELISA kits. Data were analyzed by the use of dependent and independent t-test.
Results: A significant reduction in serum levels of MDA and a significant increase in
TAOC was observed in the experimental group (P = 0.003, P = 0.001).Aerobic fitness
improved significantly also (P = 0.001).
Conclusions: Regular moderate-intensity aerobic exercise can prevent the recurrence of
breast cancer by improving the body’s antioxidant defense and aerobic fitness.
Select article type: Original/Research Article |
Received: 2017/10/30 | Accepted: 2017/10/30 | ePublished: 2017/10/30
Received: 2017/10/30 | Accepted: 2017/10/30 | ePublished: 2017/10/30
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