Hydrogels are often exploited biological materials in the transfer of biomolecules such as medications, DNA, and proteins owing to apparent features, including cytocompatibility and likeness to genuine human tissues. A number of biomaterials have the capacity to be injected, which allows for minimum invasion and eliminates the necessity of surgery to transplant pre-formed materials. This material is injected through the target location in a solution condition before gelling. If a stimulus generates gelation by the interaction of one or more stimuli, it can do so spontaneously. When such occurs, the material/system is referred to be stimuli-responsive since it reacts to its environment. In this context, we discussed the many triggers leading to gelation and reviewed the various processes by which the solution becomes a gel. We also reviewed several trials that used these gels to treat cancer. These materials show promise for treating cancer. Injectable hydrogels and stimuli-sensitive materials were the topics of several studies and reviews. To our knowledge, there has not been any research done on the use of smart injectable hydrogels for tumor therapy.
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