Multidisciplinary Cancer Investigation
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Volume 7, Issue 3 (Multidisciplinary Cancer Investigation 2023)
Multidiscip Cancer Investig 2023, 7(3): 9-20 |
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Tamaddon P, Perota G, Dehdari Vais R, Sattarahmady N. Cumulative Effect of a Gold-Poly(o-aminophenol) Nanocomposite and Doxorubicin in Photothermal Therapy, Sonodynamic Therapy, and Chemotherapy of Breast Cancer (MCF-7 Cell Line). Multidiscip Cancer Investig 2023; 7 (3) :9-20
URL: http://mcijournal.com/article-1-379-en.html
URL: http://mcijournal.com/article-1-379-en.html
1- Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , paria.tmdn@gmail.com
2- Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2- Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract: (380 Views)
Introduction: Nowadays, the applications of non-invasive treating cancer methods such as photothermal therapy (PTT) and sonodynamic therapy (SDT) are increasing. These treatments use photo/sonosensitizers, which are activated after being exposed by laser light irradiation and ultrasound (US) exposure, respectively.
Methods: Herein, a gold-poly (ortho-aminophenol) nanocomposite (Au-PoAP NC) with a spherical shape, a diameter of 46±8 nm was synthesized and evaluated as an 808-nm laser photosensitizer (with 30% photothermal efficiency) and a sonosensitizer upon US exposure. Additionally, Au-PoAP NC was appraised with doxorubicin (as a chemotherapy agent) for treating breast cancer cells. The MTT test was done for cell-toxicity evaluation of Au-PoAP NC, doxorubicin, and Au-PoAP NC with doxorubicin with or without irradiation and US exposure (separately and synchronously).
Results: The results proved that light irradiation and US exposure (separately and synchronously) of Au-PoAP NC with doxorubicin significantly enhanced the cell toxicity in other treatment groups. Moreover, cytotoxicity of Au-PoAP NC, doxorubicin, and Au-PoAP NC with doxorubicin toward MCF-7 cells upon PTT and/or SDT was investigated from the aspect of reactive oxygen species (ROS) formation. Calculating the combination indices revealed that synchronous administration of Au-PoAP NC and doxorubicin and light irradiation and US exposure represented a synergistic therapeutic manner for treating cancer cells.
Conclusion: This study proved that the synchronous combination of PTT and SDT using Au-PoAP NC with doxorubicin would be an exemplary approach for treating the breast cancer cell line of MCF-7.
Methods: Herein, a gold-poly (ortho-aminophenol) nanocomposite (Au-PoAP NC) with a spherical shape, a diameter of 46±8 nm was synthesized and evaluated as an 808-nm laser photosensitizer (with 30% photothermal efficiency) and a sonosensitizer upon US exposure. Additionally, Au-PoAP NC was appraised with doxorubicin (as a chemotherapy agent) for treating breast cancer cells. The MTT test was done for cell-toxicity evaluation of Au-PoAP NC, doxorubicin, and Au-PoAP NC with doxorubicin with or without irradiation and US exposure (separately and synchronously).
Results: The results proved that light irradiation and US exposure (separately and synchronously) of Au-PoAP NC with doxorubicin significantly enhanced the cell toxicity in other treatment groups. Moreover, cytotoxicity of Au-PoAP NC, doxorubicin, and Au-PoAP NC with doxorubicin toward MCF-7 cells upon PTT and/or SDT was investigated from the aspect of reactive oxygen species (ROS) formation. Calculating the combination indices revealed that synchronous administration of Au-PoAP NC and doxorubicin and light irradiation and US exposure represented a synergistic therapeutic manner for treating cancer cells.
Conclusion: This study proved that the synchronous combination of PTT and SDT using Au-PoAP NC with doxorubicin would be an exemplary approach for treating the breast cancer cell line of MCF-7.
Select article type: Original/Research Article |
Subject:
Genetics
Received: 2023/01/28 | Accepted: 2023/06/29 | ePublished: 2023/07/12
Received: 2023/01/28 | Accepted: 2023/06/29 | ePublished: 2023/07/12
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