Multidisciplinary Cancer Investigation
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Volume 7, Issue 1 (Multidisciplinary Cancer Investigation 2023)
Multidiscip Cancer Investig 2023, 7(1): 17-26 |
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Vijithananda S, Jayatilake M, Goncalves T, Rato L, Weerakoon B, Kalupahana T D, et al . Discriminating Malignant and Benign Brain Tumors Using Texture Features Of MRI-ADC Images. Multidiscip Cancer Investig 2023; 7 (1) :17-26
URL: http://mcijournal.com/article-1-365-en.html
URL: http://mcijournal.com/article-1-365-en.html
Sahan Vijithananda1 
, Mohan Jayatilake 2, Teresa Goncalves3 , Luis Rato3 , Bimali Weerakoon4 , Tharindu D Kalupahana5 , Anil De Silva6 , Karuna Dissanayake7 , Badra Hewavithana1
, Mohan Jayatilake 2, Teresa Goncalves3 , Luis Rato3 , Bimali Weerakoon4 , Tharindu D Kalupahana5 , Anil De Silva6 , Karuna Dissanayake7 , Badra Hewavithana1
1- Department of Radiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
2- Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka ,jayatiml@pdn.ac.lk
3- Department of Informatics, School of Science and Technology, University of Evora, Evora, Portugal
4- Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka
5- Department of Computer Engineering, Faculty of Engineering, University of Sri Jayewardenepura, Ratmalana, Sri Lanka
6- Department of Radiology, National Hospital of Sri Lanka, Colombo, Sri Lanka
7- Department of Histopathology, National Hospital of Sri Lanka, Colombo, Sri Lanka
2- Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka ,
3- Department of Informatics, School of Science and Technology, University of Evora, Evora, Portugal
4- Department of Radiography/Radiotherapy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka
5- Department of Computer Engineering, Faculty of Engineering, University of Sri Jayewardenepura, Ratmalana, Sri Lanka
6- Department of Radiology, National Hospital of Sri Lanka, Colombo, Sri Lanka
7- Department of Histopathology, National Hospital of Sri Lanka, Colombo, Sri Lanka
Abstract: (1343 Views)
Introduction: The diagnosis of brain tumors often involves the use of Magnetic Resonance Imaging (MRI), with the Apparent Diffusion Coefficient (ADC) being a commonly employed technique in current clinical practice. This study seeks to investigate the potential of using statistical texture analysis of MRI-ADC images to distinguish between malignant and benign brain tumors.
Methods: The research utilized 980 MRI brain ADC image slices labeled as malignant and 805 labeled as benign from 252 subjects. The clinical diagnosis of each participant was verified by histopathological and radiological reports. The region of interest (ROI) was defined to extract ADC values within the tumor areas. From each ROI, statistical features including higher-order moments of ADC, mean pixel value, and texture features of Grey Level Co-occurrence Matrix (GLCM) were extracted along with patient demographic information. The mean feature values for each category were computed and analyzed using a one-tailed P value test at a 95% confidence level.
Results: The average pixel value of ADC, as well as the GLCM texture features (Variance 1, Variance 2, Mean 1, Mean 2, Contrast, and Energy), were found to be significantly higher (P<0.05) for benign tumors. In Contrast, malignant tumors exhibited significantly higher values for kurtosis of ADC and GLCM texture features (Entropy, Homogeneity, and Correlation). The patient's age and other features (skewness of ADC, GLCM texture features such as Shade, Entropy, and Prominence) did not provide sufficient evidence to reject the null hypothesis (P>0.05).
Conclusions: In conclusion, the aforementioned features, with the exception of the patient's age, skewness, and GLCM features such as Entropy, Shade, and Prominence can be used as potential biomarkers for distinguishing between benign and malignant brain tumors.
Methods: The research utilized 980 MRI brain ADC image slices labeled as malignant and 805 labeled as benign from 252 subjects. The clinical diagnosis of each participant was verified by histopathological and radiological reports. The region of interest (ROI) was defined to extract ADC values within the tumor areas. From each ROI, statistical features including higher-order moments of ADC, mean pixel value, and texture features of Grey Level Co-occurrence Matrix (GLCM) were extracted along with patient demographic information. The mean feature values for each category were computed and analyzed using a one-tailed P value test at a 95% confidence level.
Results: The average pixel value of ADC, as well as the GLCM texture features (Variance 1, Variance 2, Mean 1, Mean 2, Contrast, and Energy), were found to be significantly higher (P<0.05) for benign tumors. In Contrast, malignant tumors exhibited significantly higher values for kurtosis of ADC and GLCM texture features (Entropy, Homogeneity, and Correlation). The patient's age and other features (skewness of ADC, GLCM texture features such as Shade, Entropy, and Prominence) did not provide sufficient evidence to reject the null hypothesis (P>0.05).
Conclusions: In conclusion, the aforementioned features, with the exception of the patient's age, skewness, and GLCM features such as Entropy, Shade, and Prominence can be used as potential biomarkers for distinguishing between benign and malignant brain tumors.
Keywords: Magnetic Resonance Imaging, Malignant Brain Neoplasm, Benign Brain Neoplasm, Diffusion Weighted MRI
Select article type: Original/Research Article |
Received: 2023/01/16 | Accepted: 2023/03/3 | ePublished: 2023/03/25
Received: 2023/01/16 | Accepted: 2023/03/3 | ePublished: 2023/03/25
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