Multidisciplinary Cancer Investigation
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Volume 8, Issue 1 (Multidisciplinary Cancer Investigation 2024)
Multidiscip Cancer Investig 2024, 8(1): 0-0 |
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Ethics code: IR.MUMS.FHMPM.REC.1402.145
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Tavana E, Andish M, Eslami S, Shayesteh V, Parvish T, Mosa Farkhani E. The Impact of Fertility Rate Changes on Breast Cancer Incidence at the Subnational Level. Multidiscip Cancer Investig 2024; 8 (1)
URL: http://mcijournal.com/article-1-392-en.html
URL: http://mcijournal.com/article-1-392-en.html
Ensieh Tavana1 
, Masoumeh Andish1 , Samaneh Eslami1 , Vajiheh Shayesteh2 , Toktam Parvish3 , Ehsan Mosa Farkhani4
, Masoumeh Andish1 , Samaneh Eslami1 , Vajiheh Shayesteh2 , Toktam Parvish3 , Ehsan Mosa Farkhani4
1- Department of Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
2- Health Vice-Chancellor of Mashhad University of Medical Sciences, Population Youth Management, Family and School Health, Mashhad, Iran
3- Economics and Development, Ferdowsi University of Mashhad, Khorasan, Mashhad, Iran
4- Department of Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran ,emf1358@yahoo.com
2- Health Vice-Chancellor of Mashhad University of Medical Sciences, Population Youth Management, Family and School Health, Mashhad, Iran
3- Economics and Development, Ferdowsi University of Mashhad, Khorasan, Mashhad, Iran
4- Department of Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran ,
Abstract: (491 Views)
An inverse association between fertility rates and breast cancer incidence has been observed at the national and global levels. However, few studies have examined this relationship using subnational data. We aimed to determine the correlation between total fertility rates (TFR) and breast cancer incidence across cities in Iran's Razavi Khorasan province between 2014 and 2019. This ecological study utilized age-standardized breast cancer incidence rates and TFRs for 28 regions of Razavi Khorasan province from 2014 to 2019. Pearson correlation coefficients assessed the TFR-incidence correlation annually. Annual percent changes (APCs) in incidence rates were estimated using linear mixed models, unadjusted and adjusted for region-level TFRs. TFR declined province-wide, with the steepest decreases in Bakharz (-45%), Torbat Jaam (-39%), and Torghab & Shandiz (-35%). Breast cancer incidence patterns were heterogeneous across cities, with significantly declining APCs in 7 regions, including Bajestan (-9.8%), Gonabad (-8.1%), and Torghab & Shandiz (-8.3%). Fertility adjustment had minimal impact on APCs. No significant correlation was observed between TFRs and incidence rates from 2014 to 2019 (correlation coefficients -0.193 to 0.193, p>0.05). In contrast to national and global trends, declining fertility rates did not correlate with increasing breast cancer incidence across Razavi Khorasan cities from 2014 to 2019. Regional differences may modify the impacts of changing fertility patterns on breast cancer occurrence. Further investigations into this relationship are warranted using robust analytical methods.
Select article type: Original/Research Article |
Subject:
Health Services, Quality of Life and Outcomes
Received: 2024/04/2 | Accepted: 2024/10/30 | ePublished: 2024/11/12
Received: 2024/04/2 | Accepted: 2024/10/30 | ePublished: 2024/11/12
References
1. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. 2019; 144(8):1941-53. DOI: 10.1002/ijc.31937 [DOI:10.1002/ijc.31937] [PMID]
2. Roshandel G., Ghanbari-Motlagh A., Partovipour E., et al. Cancer incidence in Iran in 2014: Results of the Iranian National Population-based Cancer Registry. Cancer Epidemiology. 2019;61(61):50-58. DOI: 10.1016/j.canep.2019.05.009 [DOI:10.1016/j.canep.2019.05.009] [PMID]
3. Youn HJ, Han W. A review of the epidemiology of breast cancer in Asia: focus on risk factors. Asian Pac J Cancer Prev. 2020;21(4):867-80. DOI: 10.31557/APJCP.2020.21.4.867 [DOI:10.31557/APJCP.2020.21.4.867] [PMID] []
4. Lee E, Doanvo N, Lee M, Soe Z, Lee AW, Van Doan C, et al. Immigration history, lifestyle characteristics, and breast density in the Vietnamese American Women's Health Study: a cross-sectional analysis. Cancer Causes Control. 2020;31(2):127-38. DOI: 10.1007/s10552-019-01264-1 [DOI:10.1007/s10552-019-01264-1] [PMID] []
5. Stordal B. Breastfeeding reduces the risk of breast cancer: A call for action in high‐income countries with low rates of breastfeeding. Cancer Medicine. 2023;12(4):4616-25. DOI: 10.1002/cam4.5288 [DOI:10.1002/cam4.5288] [PMID] []
6. Zahedi R, Molavi Vardanjani H, Baneshi MR, Haghdoost AA, Malekpour Afshar R, Ershad Sarabi R, et al. Incidence trend of breast cancer in women of eastern Mediterranean region countries from 1998 to 2019: A systematic review and meta-analysis. BMC Womens Health. 2020 Mar 17;20(1):53. DOI: 10.1186/s12905-020-00903-z [DOI:10.1186/s12905-020-00903-z] [PMID] []
7. Fitzmaurice C, Abate D, Abbasi N, Abbastabar H, Abd-Allah F, Abdel-Rahman O, et al. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2019 1;5(12):1749-1768. DOI: 10.1001/jamaoncol.2019.2996 [DOI:10.1001/jamaoncol.2019.2996] [PMID] []
8. Abbasi-Shavazi MJ, Mahmoudian H, Sadeghi R, Ghorbani Z. The impact of value-attitude orientations on the ideals of childbearing in Iran. Journal of Population Association of Iran. 2019 ,21;13(26):37-66. DOI: 20.1001.1.1735000.1397.13.26.2.4
9. Khoramdad, M., Solaymani-Dodaran, M., Kabir, A. et al. Breast cancer risk factors in Iranian women: a systematic review and meta-analysis of matched case-control studies. Eur J Med Res 27, 311 (2022). DOI: 10.1186/s40001-022-00952-0 [DOI:10.1186/s40001-022-00952-0] [PMID] []
10. Lim YX, Lim ZL, Ho PJ, Li J. Breast Cancer in Asia: Incidence, Mortality, Early Detection, Mammography Programs, and Risk-Based Screening Initiatives. Cancers (Basel). 2022: 30;14(17):4218. DOI: 10.3390/cancers14174218 [DOI:10.3390/cancers14174218] [PMID] []
11. Parazzini F, Gadducci A, Cicinelli E, Maggino T, Peccatori F, Scarfone G, et al. Pregnancy-associated cancers: frequency and temporal trends in Italy. International Journal of Gynecologic Cancer. 2020:1;30(2). DOI: 10.1136/ijgc-2019-000828 [DOI:10.1136/ijgc-2019-000828] [PMID]
12. Duarte C, Salazar A, Strasser-Weippl K, de Vries E, Wiesner C, Arango-Gutiérrez A, et al. Breast cancer in Colombia: a growing challenge for the healthcare system. Breast cancer research and treatment. 2021; 186:15-24. DOI: 10.1007/s10549-020-06091-6 [DOI:10.1007/s10549-020-06091-6] [PMID]
13. Akbari ME, Akbari A, Khayamzadeh M, Salmanian R, Akbari M. Ten-year survival of breast cancer in Iran: a national study (Retrospective cohort study). Breast Care. 2023: 28;18(1):12-21. DOI: 10.1159/000526746 [DOI:10.1159/000526746] [PMID] []
14. Shamshirian A, Heydari K, Shams Z, Aref AR, Shamshirian D, Tamtaji oR, Asemi Z, et al. Breast cancer risk factors in Iran: a systematic review & meta-analysis. Hormone Molecular Biology and Clinical Investigation. 2020 Dec 14;41(4):20221. DOI: 10.1515/hmbci-2020-0021 [DOI:10.1515/hmbci-2020-0021] [PMID]
15. The World Bank. Fertility rate, total (births per woman) - Iran, Islamic Rep. https://data.worldbank.org/indicator/SP.DYN.TFRT.IN?locations=IR
16. Roshandel G, Ghanbari-Motlagh A, Partovipour E, Salavati F, Hasanpour-Heidari S, Mohammadi G, et al. Cancer incidence in Iran in 2014: Results of the Iranian National Population-based Cancer Registry. Cancer Epidemiol. 2019 Aug;61:50-58. doi: 10.1016/j.canep.2019.05.009. DOI: 10.1016/j.canep.2019.05.009 [DOI:10.1016/j.canep.2019.05.009] [PMID]
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