Multidisciplinary Cancer Investigation
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Volume 8, Issue 1 (Multidisciplinary Cancer Investigation 2024)
Multidiscip Cancer Investig 2024, 8(1): 0-0 |
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Kordkatouli M, Mohammadi bondarkhilli S A, Sateei A, Mahmood Janlou M A. Roles of miR-21 in the Onset and Advancement of Colorectal Cancer (CRC). Multidiscip Cancer Investig 2024; 8 (1)
URL: http://mcijournal.com/article-1-394-en.html
URL: http://mcijournal.com/article-1-394-en.html
Mohammad Kordkatouli1 
, Seyed abolghassem Mohammadi bondarkhilli 2, Aryan Sateei1 , Mehr Ali Mahmood Janlou1
, Seyed abolghassem Mohammadi bondarkhilli 2, Aryan Sateei1 , Mehr Ali Mahmood Janlou1
1- Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
2- Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran ,sambondar2@gmail.com
2- Department of Biology, Gorgan Branch, Islamic Azad University, Gorgan, Iran ,
Abstract: (1070 Views)
MiR-21 is a critical small regulatory RNA involved in various cellular processes such as cell cycle, apoptosis, migration, and differentiation of stem cells. It is significantly upregulated in CRC cell lines and tissue samples, acting as a biomarker and playing an important role in the pathogenesis of CRC. MiR-21 targets and downregulates tumor suppressor genes such as PDCD4, which are part of the PI3K- mTOR pathway. The inverse relationship between miR-21 and PDCD4 expression highlights the miR-21 role in CRC progression. Research shows that miR-21 is upregulated in human CRC cell lines and tissue samples, correlating with advanced clinical stages, lymph node metastasis, and poor prognosis. This regulation highlights the potential of miR-21 as a biomarker for the early detection of CRC and as a therapeutic target for developing targeted therapies. MiR-21 regulates several CRC-related target genes, highlighting its role in cancer initiation, transformation, invasion, and metastasis. These findings provide valuable insights into miR-21's role in cancer pathogenesis and its potential clinical applications.
Select article type: Review Article |
Subject:
Genetics
Received: 2024/04/21 | Accepted: 2024/08/7 | ePublished: 2024/08/20
Received: 2024/04/21 | Accepted: 2024/08/7 | ePublished: 2024/08/20
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