Volume 2, Issue 3 (Multidisciplinary Cancer Investigation 2018)                   Multidiscip Cancer Investig 2018, 2(3): 1-11 | Back to browse issues page

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Majid S, Bhat S A, Rehman M U. Diagnostic utility of miRNAs in cancer A review. Multidiscip Cancer Investig. 2018; 2 (3) :1-11
URL: http://mcijournal.com/article-1-197-en.html
Abstract:   (68 Views)
Cancer is the most prevalent and leading cause of death in the world. Current advancement in technology has improved the understanding of the pathogenesis and pathology of cancers. But due to high mortality rates, unfavorable prognosis and lack of clinical predictive biomarkers provide an impetus to investigate novel early diagnostic/prognostic markers and therapeutic targets for cancers, which is sufficiently sensitive to cancers. Recently, the small noncoding microRNAs (miRNAs) have been suggested to be critical regulators in the oncogenesis pathways and to serve as useful clinical biomarkers. This new class of biomarkers is emerging as a novel molecule for cancer diagnosis and prognosis and recent miRNA expression profiling in primary tumors has yielded promising results. However, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA determination in oncology. Since determination of miRNAs in peripheral blood, either cell-free is expected to become important in oncology. A better understanding of the involvement of miRNAs in carcinogenesis could provide insights into the mechanisms of tumor development and could help to identify novel early powerful markers for the early detection of Cancer. In this review, we summarizes the recent research studies supporting the utility of miRNAs as novel early diagnostic and prognostic tools, thus potentially illuminating future treatment strategies for cancers which indicates the feasibility and clinical applications of miRNAs in cancer for researchers and clinical diagnostic centers
Full-Text [PDF 1276 kb]   (6 Downloads)    
Type of Study: Review Article | Subject: diagnosis
Received: 2018/05/22 | Accepted: 2018/07/14 | ePublished: 2018/08/7

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